كقاعدة عامة، يتم علاج الملاريا بأدوية تسمى مبيدات الشيزونتوسيد. هذه الأدوية لها تأثير مضاد للطفيليات. وبسبب الاستخدام الواسع للعقاقير في الماضي، فإن العديد من مسببات الأمراض تقاوم بالفعل بعض الأدوية، ولهذا السبب غالباً ما يتم الجمع بين اثنين أو أكثر من المواد الفعالة في العلاج.
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